In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. Paget (...) described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

This piece is an essay review of Wang Hui's book China from Empire to Nation-State, which is a translation of the introduction to Wang's four-volume Rise of Modern Chinese Thought. According to the reviewer, Wang studies less the modern history of China than its historicity and does so in the context of China's transition from being an empire, inhabiting a cosmos that is the product of its own self-reflection, to being one among a number of nation-states, inhabiting (...) a number of histories of their own, all of which are now simultaneously present. But the Euro-American terms empire and nation-state, which increasingly pervade Chinese perceived realities, lack precise Chinese equivalents. Meanwhile, the terms that the Chinese use in referring to the same historical transition, tianli and gongli, are obscure to the Euro-American mind. The reviewer asks whether the Chinese, now facing a plurality of histories, wonder if there may be a plurality of li, as well, or at least if there can be a li that is “universal” in the sense that it is common to them all. The problem here, the reviewer argues, in part derives from Wang's binaries being Hegelian, while the breakdown of the nation-state in Europe projects a postpolitical order in which human communities are incapable of state-based action or of determining their own li. The review ends by questioning whether China is capable of following this path and, in any case, whether Wang's vocabulary is able to encompass it. (shrink)

Dialetheism is the view that there are true contradictions. Classical dialetheism holds further the view that the law of excluded middle is indeed a logical law. Most famous dialetheists, such as G. Priest and J. Beall, are classical dialetheists; they take classical dialetheism to be the only plausible solution to the semantic paradoxes. The main contention of the paper is, however, that their views should be rejected. Based on inspecting Priest’s and Beall’s dialetheist theories from a special perspective, this paper (...) contends that classical dialetheism has no natural and plausible way to assign truth values to various truth-ineliminable sentences, i.e., sentences whose truth-conditions essentially involve the property of being true . Several examples of such truth-ineliminable sentences are given in the paper, and two classical dialetheist strategies for assigning them truth values are inspected. This paper argues that none of these strategies is successful. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

There is great skepticism about the admittance of expert normative ethics testimony into evidence. However, a practical analysis of the way ethics testimony has been used in courts of law reveals that the skeptical position is itself based on assumptions that are controversial. We argue for an alternative way to understand such expert testimony. This alternative understanding is based on the practice of clinical ethics.

This paper is aimed at a critical assessment of the moral framework of the current Chinese health system from a Confucian perspective, by focusing on the debate between the individual directed approach and the family-oriented approach to a health care system. Concerned with the nature and status of the family in communal life, the paper deals with the following questions: to cope with the frailties of material life (including susceptibility to disease), what good is presupposed by human existence and flourishing; (...) why it is the family that serves as the primary locus of bearing and realizing this unique good; and what kind of society might possess the structures necessary to achieve the good thus conceived. All these questions lead to a revision of the theory of justice required in health care, in favor of family health saving accounts as an important institutional guarantee. (shrink)